Overall Equipment Effectiveness within Counterfactual Impact Evaluation Concept

Counterfactual impact evaluation (CIE) is a scientific quantitative approach mainly based on experiments and quasi experiments. CIE is trying to prove a causal relationship between outputs and outcomes. CIE does not take into account coherence of external incentives of companies with internal incentives that have or may have an impact on the behaviour of enterprises. The paper sets up internal evaluation indicators for businesses, counterfactuals useful for creating a more complex metrics evaluating businesses in the area of performance. The aim of the paper is to present model situation using the elementary principle of counterfactual impact evaluation based on “the Overall Equipment Effectiveness (OEE)”.JEL Codes - M11; M21; M2

ARIA-EAACI statement on asthma and COVID-19 (June 2, 2020)

Non peer reviewe

Management of anaphylaxis due to COVID-19 vaccines in the elderly

Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.Peer reviewe

ARIA 2016 : Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.Peer reviewe

Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018) : Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline by using the best approach to integrated care pathways using mobile technology in patients with allergic rhinitis (AR) and asthma multimorbidity. The proposed next phase of ARIA is change management, with the aim of providing an active and healthy life to patients with rhinitis and to those with asthma multimorbidity across the lifecycle irrespective of their sex or socioeconomic status to reduce health and social inequities incurred by the disease. ARIA has followed the 8-step model of Kotter to assess and implement the effect of rhinitis on asthma multimorbidity and to propose multimorbid guidelines. A second change management strategy is proposed by ARIA Phase 4 to increase self-medication and shared decision making in rhinitis and asthma multimorbidity. An innovation of ARIA has been the development and validation of information technology evidence-based tools (Mobile Airways Sentinel Network [MASK]) that can inform patient decisions on the basis of a self-care plan proposed by the health care professional.Peer reviewe

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

Stratigraphy of the Lower Part of the Baška Formation

Import 02/11/2016Diplomová práce se zabývá litologickou, stratigrafickou minulostí horninového prostředí slezské jednotky na území Moravskoslezských Beskyd a Podbeskydské pahorkatiny. Konkrétně profilem na potoku Ondřejnice blízko města Hukvaldy v České republice. Je to zjišťováno pomocí analýzy odebraných hornin laboratorními metodami. Cílem práce je potvrdit hranici mezi svrchnocenomanským a spodnoturonským stářím hornin pomocí forminifer, a svrchnocenomanské stáří určené při I. etapě průzkumu profilu. Byly nově objeveny pestré vrstvy v bašském souvrství, které se také nazývají redbeds. Byly podrobeny laboratorním analýzám, určeným k zjištění jejich minerálního složení a možné existence konkrecí oxidů Mn a Fe.The thesis deals with lithological, stratigraphic past by geological environment the Silesian unit on the territory of the Moravian-Silesian Beskydy and Podbeskydská upland. Specifically, it is profile on stream of Ondřejnice near to Hukvaldy in the Czech Republic. It is ascertained by analyzing collected rocks by laboratory methods. The aim is to confirm the boundary between late Cenomanian and early Turonian age of rocks through forminifer and upper cenomanian age specified in the first phase of exploration profile. They were rediscovered the colorful layers in the Baška Formation, which are also called the redbeds. Were subjected to laboratory analyzes designed to determine their mineral composition and the possible presence of concretions of oxides of Mn and Fe.Prezenční541 - Institut geologického inženýrstvívelmi dobř

Cyclic Sedimentation in Štramberk Limestone

Import 26/06/2013Tato bakalářská práce se zabývá cyklickou sedimentací ve štramberském vápenci. Cílem práce je makropopis a mikropopis nalezených vrstev, a na to navazuje stratigrafické datování dle nalezených organizmů. Hlavně se jedná o zástupce amonitů a kalpionel. V druhé kapitole je charakterizováno jurské období od základních parametrů až po určení vlastností štramberského vápence. Další kapitola je pojednává o sedimentaci karbonátů. Čtvrtá kapitola je zaměřena na metodiku práce a lokalizaci odběru vzorků. Další kapitola popisuje makropisné prvky jednotlivých vrstev, tvorbu výbrusů a mikropopis jednotlivých výbrusů. Závěr práce popisuje společné prvky daných vrstev, za jakých podmínek části vrstev sedimentovaly, vyjmenovává nejčastější vůdčí zkameněliny spolu s jejich časovým zařazením.This bachelor thesis deals with cyclic sedimentation in Štramberk limestone. Purpose of thesis is macrospecification and microspecification of found layers, and it continues stratigraphic dating by organisms found. Mainly it is a representative ammonites and calpionels. The second part describes the Jurassic period, from basic parameters to determine the properties Štramberk limestone. The next chapter discusses the sedimentation of carbonates. The fourth chapter focuses on the methodology of work and location of sampling. The next chapter describes macrospecification elements of each layer, making cuts and mickospecification individual samples. Conclusion of the thesis describes the common elements of these layers, the conditions under which the layers of sedimentation, lists the most common index fossils along with their temporal classification.Prezenční541 - Institut geologického inženýrstvívýborn